{"id":375226,"date":"2025-01-03T13:50:54","date_gmt":"2025-01-03T18:50:54","guid":{"rendered":"https:\/\/caiready.com\/life-sciences\/blog\/%e6%9c%aa%e6%9d%a5%e3%82%92%e9%96%8b%e3%81%8f%ef%bc%9a%e6%9c%80%e5%85%88%e7%ab%af%e3%81%ae%e7%b4%b0%e8%83%9e%e3%83%bb%e9%81%ba%e4%bc%9d%e5%ad%90%e6%b2%bb%e7%99%82%e3%82%92%e6%8e%a2%e3%82%8b\/"},"modified":"2025-01-03T13:50:54","modified_gmt":"2025-01-03T18:50:54","slug":"%e6%9c%aa%e6%9d%a5%e3%82%92%e9%96%8b%e3%81%8f%ef%bc%9a%e6%9c%80%e5%85%88%e7%ab%af%e3%81%ae%e7%b4%b0%e8%83%9e%e3%83%bb%e9%81%ba%e4%bc%9d%e5%ad%90%e6%b2%bb%e7%99%82%e3%82%92%e6%8e%a2%e3%82%8b","status":"publish","type":"post","link":"https:\/\/caiready.com\/life-sciences\/ja\/blog\/%e6%9c%aa%e6%9d%a5%e3%82%92%e9%96%8b%e3%81%8f%ef%bc%9a%e6%9c%80%e5%85%88%e7%ab%af%e3%81%ae%e7%b4%b0%e8%83%9e%e3%83%bb%e9%81%ba%e4%bc%9d%e5%ad%90%e6%b2%bb%e7%99%82%e3%82%92%e6%8e%a2%e3%82%8b\/","title":{"rendered":"\u672a\u6765\u3092\u958b\u304f\uff1a\u6700\u5148\u7aef\u306e\u7d30\u80de\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u63a2\u308b"},"content":{"rendered":"\n

\u672a\u6765\u3092\u958b\u304f\uff1a\u6700\u5148\u7aef\u306e\u7d30\u80de\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u63a2\u308b<\/h2>\n

\u7d30\u80de\u6cbb\u7642\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u533b\u5b66\u306e\u4e16\u754c\u306f\u5909\u9769\u306e\u771f\u3063\u305f\u3060\u4e2d\u306b\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u6700\u5148\u7aef\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u75c5\u6c17\u306e\u6839\u672c\u539f\u56e0\u304b\u3089\u53d6\u308a\u7d44\u3080\u6709\u671b\u306a\u624b\u6bb5\u3092\u63d0\u4f9b\u3057\u3001\u4ee5\u524d\u306f\u6cbb\u7642\u4e0d\u53ef\u80fd\u3068\u3055\u308c\u3066\u3044\u305f\u75c5\u614b\u306b\u5e0c\u671b\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002\u3053\u306e\u30d6\u30ed\u30b0\u3067\u306f\u3001\u6700\u3082\u753b\u671f\u7684\u306a\u7d30\u80de\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u3044\u304f\u3064\u304b\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u305d\u306e\u958b\u767a\u65b9\u6cd5\u3001\u7d30\u80de\u30fb\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b\u3092\u63a2\u308b\u3002 <\/p>\n

1.CAR-T\u7d30\u80de\u7642\u6cd5<\/h4>\n

\u958b\u767a\u65b9\u6cd5<\/strong>\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53T\u7d30\u80de\uff08CAR-T\uff09\u7642\u6cd5\u306f\u3001\u60a3\u8005\u306eT\u7d30\u80de\u3092\u3001\u304c\u3093\u7d30\u80de\u3092\u3088\u308a\u3088\u304f\u8a8d\u8b58\u3057\u653b\u6483\u3059\u308b\u3088\u3046\u306b\u907a\u4f1d\u5b50\u64cd\u4f5c\u3059\u308b\u753b\u671f\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308b\u3002\u3053\u306e\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u60a3\u8005\u304b\u3089T\u7d30\u80de\u3092\u53d6\u308a\u51fa\u3057\u3001\u7279\u5b9a\u306e\u304c\u3093\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53\uff08CAR\uff09\u3092\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u5b9f\u9a13\u5ba4\u3067\u6539\u5909\u3057\u3001\u3053\u306e\u6539\u5909\u7d30\u80de\u3092\u518d\u3073\u60a3\u8005\u306e\u4f53\u5185\u306b\u623b\u3059\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f\uff1a<\/strong>\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306f\u3001CAR-T\u7d30\u80de\u306f\u304c\u3093\u7d30\u80de\u8868\u9762\u306e\u6297\u539f\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6a5f\u80fd\u3059\u308b\u3002CAR\u30b3\u30f3\u30b9\u30c8\u30e9\u30af\u30c8\u306f\u901a\u5e38\u3001\u816b\u760d\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3068\u3001\u6297\u539f\u7d50\u5408\u6642\u306bT\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3059\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30c9\u30e1\u30a4\u30f3\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u3002\u3053\u306e\u4e8c\u91cd\u6a5f\u80fd\u6027\u306b\u3088\u308a\u3001CAR-T\u7d30\u80de\u306f\u3001\u5065\u5eb7\u306a\u7d30\u80de\u3092\u6e29\u5b58\u3057\u306a\u304c\u3089\u3001\u304c\u3093\u7d30\u80de\u3092\u7279\u7570\u7684\u306b\u540c\u5b9a\u3057\u3001\u7834\u58ca\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b<\/strong>\u6700\u3082\u6709\u540d\u306aCAR-T\u7642\u6cd5\u306e\u3072\u3068\u3064\u306f\u3001\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u793e\u304c\u958b\u767a\u3057\u305fKymriah\uff08tisagenlecleucel\uff09\u3067\u3042\u308b\u3002\u7279\u5b9a\u306e\u30bf\u30a4\u30d7\u306eB\u7d30\u80de\u6027\u6025\u6027\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u767d\u8840\u75c5\uff08ALL\uff09\u3068\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

2.CRISPR-Cas9\u907a\u4f1d\u5b50\u7de8\u96c6<\/h4>\n

\u958b\u767a\u65b9\u6cd5<\/strong>CRISPR-Cas9\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306f\u3001DNA\u3092\u6539\u5909\u3059\u308b\u305f\u3081\u306e\u7cbe\u5bc6\u304b\u3064\u52b9\u7387\u7684\u306a\u65b9\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u9769\u547d\u3092\u3082\u305f\u3089\u3057\u305f\u3002\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u6a19\u7684DNA\u914d\u5217\u306b\u76f8\u88dc\u7684\u306a\u30ac\u30a4\u30c9RNA\uff08gRNA\uff09\u3092\u8a2d\u8a08\u3059\u308b\u3002gRNA\u306fCas9\u9175\u7d20\u3068\u3068\u3082\u306b\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3055\u308c\u3001Cas9\u304c\u6a19\u7684\u90e8\u4f4d\u3067\u4e8c\u672c\u9396\u5207\u65ad\u3092\u8a98\u5c0e\u3057\u3001\u907a\u4f1d\u7269\u8cea\u306e\u633f\u5165\u3001\u6b20\u5931\u3001\u4fee\u6b63\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f\uff1a<\/strong>\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u3001CRISPR-Cas9\u30b7\u30b9\u30c6\u30e0\u306f\u5206\u5b50\u306f\u3055\u307f\u306e\u3088\u3046\u306b\u4f5c\u52d5\u3059\u308b\u3002gRNA\u306fCas9\u3092\u7279\u5b9a\u306eDNA\u914d\u5217\u306b\u8a98\u5c0e\u3057\u3001Cas9\u306f\u305d\u3053\u3067\u6b63\u78ba\u306a\u5207\u65ad\u3092\u884c\u3046\u3002\u305d\u306e\u5f8c\u3001\u975e\u76f8\u540c\u672b\u7aef\u63a5\u5408\uff08\u5c0f\u3055\u306a\u633f\u5165\u3084\u6b20\u5931\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff09\u307e\u305f\u306f\u76f8\u540c\u6307\u5411\u6027\u4fee\u5fa9\uff08\u63d0\u4f9b\u3055\u308c\u305f\u5834\u5408\u3001\u65b0\u3057\u3044DNA\u65ad\u7247\u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\uff09\u306e\u3044\u305a\u308c\u304b\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u306e\u81ea\u7136\u306aDNA\u4fee\u5fa9\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u4f5c\u52d5\u3059\u308b\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u75c5\u6c17\u306e\u539f\u56e0\u3068\u306a\u308b\u7a81\u7136\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u6027\u75be\u60a3\u3092\u6cbb\u7642\u3059\u308b\u8a08\u308a\u77e5\u308c\u306a\u3044\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b<\/strong>\u81e8\u5e8a\u8a66\u9a13\u4e2d\u306e\u5148\u99c6\u7684\u306aCRISPR\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u6cd5\u306e\u3072\u3068\u3064\u306b\u3001CRISPR Therapeutics\u793e\u3068Vertex Pharmaceuticals\u793e\u304c\u958b\u767a\u3057\u305fCTX001\u304c\u3042\u308b\u3002CTX001\u306f\u938c\u72b6\u8d64\u8840\u7403\u75c7\u3084\u03b2\u30b5\u30e9\u30bb\u30df\u30a2\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

3.\u5e79\u7d30\u80de\u6cbb\u7642<\/h4>\n

\u958b\u767a\u65b9\u6cd5\uff1a<\/strong>\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u306f\u3001\u69d8\u3005\u306a\u7d30\u80de\u578b\u306b\u5206\u5316\u3059\u308b\u53ef\u80fd\u6027\u3092\u6301\u3063\u305f\u591a\u80fd\u6027\u5e79\u7d30\u80de\u3084\u591a\u80fd\u6027\u5e79\u7d30\u80de\u3092\u7528\u3044\u308b\u3002\u305d\u306e\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u9aa8\u9ac4\u3084\u8102\u80aa\u7d44\u7e54\u3001\u3042\u308b\u3044\u306f\u4f53\u7d30\u80de\u304b\u3089\u8a98\u5c0e\u3055\u308c\u305f\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPS\u7d30\u80de\uff09\u306a\u3069\u306e\u4f9b\u7d66\u6e90\u304b\u3089\u5e79\u7d30\u80de\u3092\u5206\u96e2\u3059\u308b\u3053\u3068\u304c\u542b\u307e\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u5e79\u7d30\u80de\u306f\u3001\u60a3\u8005\u306b\u79fb\u690d\u3055\u308c\u308b\u524d\u306b\u57f9\u990a\u3055\u308c\u3001\u76ee\u7684\u306e\u7d30\u80de\u578b\u306b\u5206\u5316\u3059\u308b\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f<\/strong>\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306f\u3001\u5e79\u7d30\u80de\u306f\u50b7\u3064\u3044\u305f\u308a\u75c5\u6c17\u306b\u306a\u3063\u305f\u308a\u3057\u305f\u7d44\u7e54\u3092\u88dc\u3046\u7279\u6b8a\u306a\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4f8b\u3048\u3070\u5fc3\u81d3\u75c5\u306e\u5834\u5408\u3001\u5e79\u7d30\u80de\u306f\u5fc3\u7b4b\u7d30\u80de\u3078\u3068\u5206\u5316\u3057\u3001\u5fc3\u81d3\u7d44\u7e54\u3068\u4e00\u4f53\u5316\u3057\u3066\u5fc3\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u640d\u50b7\u3057\u305f\u7d44\u7e54\u3092\u518d\u751f\u3055\u305b\u308b\u5e79\u7d30\u80de\u306e\u80fd\u529b\u306f\u3001\u810a\u9ac4\u640d\u50b7\u304b\u3089\u795e\u7d4c\u5909\u6027\u75be\u60a3\u307e\u3067\u3001\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306b\u5bfe\u3057\u3066\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b\uff1a<\/strong>\u30aa\u30b7\u30ea\u30b9\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u304c\u958b\u767a\u3057\u305f\u30d7\u30ed\u30ad\u30de\u30eb\u306f\u3001\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff08GvHD\uff09\u306a\u3069\u306e\u6cbb\u7642\u306b\u9aa8\u9ac4\u7531\u6765\u306e\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u3092\u4f7f\u7528\u3059\u308b\u3002<\/p>\n

4.\u816b\u760d\u6eb6\u89e3\u6027\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5<\/h4>\n

\u958b\u767a\u65b9\u6cd5<\/strong>\u816b\u760d\u6eb6\u89e3\u6027\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306f\u3001\u304c\u3093\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u611f\u67d3\u3057\u3066\u6b7b\u6ec5\u3055\u305b\u308b\u907a\u4f1d\u5b50\u64cd\u4f5c\u30a6\u30a4\u30eb\u30b9\u3092\u5229\u7528\u3059\u308b\u3002\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\uff08HSV\uff09\u3084\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u3092\u6539\u5909\u3057\u3066\u3001\u816b\u760d\u9078\u629e\u6027\u3068\u5b89\u5168\u6027\u3092\u9ad8\u3081\u308b\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u64cd\u4f5c\u3055\u308c\u305f\u30a6\u30a4\u30eb\u30b9\u306f\u60a3\u8005\u306b\u6295\u4e0e\u3055\u308c\u3001\u816b\u760d\u7d30\u80de\u306b\u611f\u67d3\u3057\u8907\u88fd\u3055\u308c\u308b\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f\uff1a<\/strong>\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u3001\u764c\u7d30\u80de\u5185\u3067\u512a\u5148\u7684\u306b\u8907\u88fd\u3059\u308b\u305f\u3081\u306b\u3001\u764c\u7d30\u80de\u5185\u306e\u5909\u5316\u3057\u305f\u7d4c\u8def\u3092\u5229\u7528\u3059\u308b\u3002\u30a6\u30a4\u30eb\u30b9\u304c\u8907\u88fd\u3055\u308c\u308b\u3068\u3001\u611f\u67d3\u3057\u305f\u304c\u3093\u7d30\u80de\u304c\u7834\u88c2\uff08\u6eb6\u89e3\uff09\u3057\u3001\u65b0\u3057\u3044\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u304c\u653e\u51fa\u3055\u308c\u3001\u96a3\u63a5\u3059\u308b\u816b\u760d\u7d30\u80de\u306b\u611f\u67d3\u3059\u308b\u3002\u3055\u3089\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306f\u6297\u816b\u760d\u514d\u75ab\u53cd\u5fdc\u3092\u523a\u6fc0\u3057\u3001\u304c\u3093\u7d30\u80de\u306e\u6392\u9664\u3092\u3055\u3089\u306b\u52a9\u3051\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b\uff1a<\/strong>\u30a2\u30e0\u30b8\u30a7\u30f3\u793e\u304c\u958b\u767a\u3057\u305fT-VEC\uff08talimogene laherparepvec\uff09\u306f\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002T-VEC\u306f\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u306b\u7531\u6765\u3057\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u523a\u6fc0\u3057\u306a\u304c\u3089\u304c\u3093\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u3066\u6bba\u50b7\u3059\u308b\u3088\u3046\u306b\u907a\u4f1d\u5b50\u6539\u5909\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

5. mRNA\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u6cd5<\/h4>\n

\u958b\u767a\u65b9\u6cd5<\/strong>COVID-19\u306emRNA\u30ef\u30af\u30c1\u30f3\u306e\u6210\u529f\u306b\u57fa\u3065\u304d\u3001\u7814\u7a76\u8005\u305f\u3061\u306fmRNA\u6280\u8853\u3092\u3055\u307e\u3056\u307e\u306a\u6cbb\u7642\u7528\u9014\u306b\u5fdc\u7528\u3059\u308b\u3053\u3068\u3092\u6a21\u7d22\u3057\u3066\u3044\u308b\u3002\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u6cbb\u7642\u7528\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308bmRNA\u914d\u5217\u3092\u30c7\u30b6\u30a4\u30f3\u3059\u308b\u3002\u3053\u308c\u3089\u306emRNA\u914d\u5217\u306f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08LNP\uff09\u306b\u5c01\u5165\u3055\u308c\u3001\u7d30\u80de\u5185\u306b\u9001\u9054\u3055\u308c\u308b\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f\uff1a<\/strong>\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306f\u3001mRNA\u306f\u7d30\u80de\u8cea\u306b\u9001\u9054\u3055\u308c\u3001\u305d\u3053\u3067\u7d30\u80de\u306e\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u6cbb\u7642\u7528\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u308b\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u764c\u3084\u907a\u4f1d\u6027\u75be\u60a3\u306a\u3069\u306e\u7279\u5b9a\u306e\u75be\u60a3\u306b\u304a\u3044\u3066\u6b20\u640d\u307e\u305f\u306f\u6b20\u9665\u306e\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7523\u751f\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002mRNA\u306f\u4e00\u904e\u6027\u3067\u3042\u308b\u305f\u3081\u3001\u6cbb\u7642\u7528\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9001\u9054\u3059\u308b\u305f\u3081\u306e\u591a\u7528\u9014\u3067\u5b89\u5168\u306a\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u306a\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b\uff1a<\/strong>\u5148\u99c6\u7684\u306a\u4f8b\u306f\u3001\u30d5\u30a1\u30a4\u30b6\u30fc\u793e\u3068\u30d0\u30a4\u30aa\u30a8\u30cc\u30c6\u30c3\u30af\u793e\u304c\u958b\u767a\u3057\u305fBNT162b2 mRNA COVID-19\u30ef\u30af\u30c1\u30f3\uff08Comirnaty\uff09\u3067\u3042\u308b\u3002\u5f53\u521d\u306fCOVID-19\u7528\u306b\u958b\u767a\u3055\u308c\u305f\u304c\u3001\u57fa\u790e\u3068\u306a\u308bmRNA\u6280\u8853\u306f\u304c\u3093\u6cbb\u7642\u3092\u542b\u3080\u4ed6\u306e\u6cbb\u7642\u7528\u9014\u306b\u3082\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

6.AAV\u3092\u4ecb\u3057\u305f\u907a\u4f1d\u5b50\u6cbb\u7642<\/h4>\n

\u958b\u767a\u65b9\u6cd5<\/strong>\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\uff08AAV\uff09\u30d9\u30af\u30bf\u30fc\u306f\u3001\u907a\u4f1d\u6027\u75be\u60a3\u60a3\u8005\u306b\u6cbb\u7642\u7528\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308b\u3002\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u6cbb\u7642\u907a\u4f1d\u5b50\u3092\u904b\u3076\u3088\u3046\u306bAAV\u30d9\u30af\u30bf\u30fc\u3092\u5de5\u5b66\u7684\u306b\u8a2d\u8a08\u3057\u3001\u3053\u306e\u30d9\u30af\u30bf\u30fc\u3092\u60a3\u8005\u306b\u6295\u4e0e\u3059\u308b\u3002AAV\u30d9\u30af\u30bf\u30fc\u306f\u3001\u6700\u5c0f\u9650\u306e\u514d\u75ab\u5fdc\u7b54\u3067\u5e45\u5e83\u3044\u7d44\u7e54\u306b\u907a\u4f1d\u5b50\u3092\u9001\u9054\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u597d\u307e\u308c\u3066\u3044\u308b\u3002 <\/p>\n

\u4f5c\u7528\u6a5f\u5e8f\uff1a<\/strong>\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u3001AAV\u30d9\u30af\u30bf\u30fc\u306f\u6cbb\u7642\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u7d30\u80de\u306b\u5c0e\u5165\u3057\u3001\u305d\u3053\u3067\u30a8\u30d4\u30bd\u30fc\u30e0\u7684\u306b\u7dad\u6301\u30fb\u767a\u73fe\u3055\u305b\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u60a3\u8005\u306b\u6b20\u640d\u3057\u3066\u3044\u308b\u6a5f\u80fd\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7523\u751f\u3055\u308c\u308b\u3002AAV\u3092\u4ecb\u3057\u305f\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u3001\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u3001\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u3001\u7279\u5b9a\u306e\u773c\u75be\u60a3\u306a\u3069\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u691c\u8a0e\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306e\u9577\u671f\u7684\u306a\u4fee\u6b63\u306e\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u3002 <\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u88fd\u54c1\u4f8b\uff1a<\/strong>\u30b9\u30d1\u30fc\u30af\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u304c\u958b\u767a\u3057\u305fLuxturna\uff08voretigene neparvovec\uff09\u306f\u3001RPE65\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u6027\u7db2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u3002Luxturna\u306fRPE65\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u7684\u30b3\u30d4\u30fc\u3092\u7db2\u819c\u7d30\u80de\u306b\u9001\u308a\u8fbc\u307f\u3001\u8996\u529b\u3092\u56de\u5fa9\u3055\u305b\u308b\u3002 <\/p>\n

\u7d50\u8ad6<\/h4>\n

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